Energy consumption analysis in turning Ti-6Al-4V alloy.

One of the major concerns in manufacturing industries include the amount of energy consumed during machining processes. Therefore, the study of the specific energy during machining must be analyzed in relation to the process parameters (feed rate, speed and depth of cut). This work demonstrates the analysis of specific cutting energy (SCE) and cutting power during titanium alloys machining under dry conditions. Turning experiments with uncoated carbide inserts were performed applying Taguchi Design of Experiments technique and analyzed the effect of speed, feed and depth of cut during turning Ti-6Al-4V titanium alloys. ANOVA was done to find out the influence of the machining parameters on energy consumption. The outcome of this analysis indicates that feed rate is the highly dominant factor responsible for the SCE of a machine tool, whereas, cutting speed was found as the influential factor affecting the power during the machining process. The environmental and economic performance for a machining process may be significantly improved by reducing energy consumption using appropriate machining conditions

Approximate and Exact Solutions in the Sense of Conformable Derivatives of Quantum Mechanics Models Using a Novel Algorithm

The entirety of the information regarding a subatomic particle is encoded in a wave function. Solving quantum mechanical models (QMMs) means finding the quantum mechanical wave function. Therefore, great attention has been paid to finding solutions for QMMs. In this study, a novel algorithm that combines the conformable Shehu transform and the Adomian decomposition method is presented that establishes approximate and exact solutions to QMMs in the sense of conformable derivatives with zero and nonzero trapping potentials. This solution algorithm is known as the conformable Shehu transform decomposition method (CSTDM). To evaluate the efficiency of this algorithm, the numerical results in terms of absolute and relative errors were compared with the reduced differential transform and the two-dimensional differential transform methods. The comparison showed excellent agreement with these methods, which means that the CSTDM is a suitable alternative tool to the methods based on the Caputo derivative for the solutions of time-fractional QMMs. The advantage of employing this approach is that, due to the use of the conformable Shehu transform, the pattern between the coefficients of the series solutions makes it simple to obtain the exact solution of both linear and nonlinear problems. Consequently, our approach is quick, accurate, and easy to implement. The convergence, uniqueness, and error analysis of the solution were examined using Banach’s fixed point theory

Antihyperglycemic and hypolipidemic potential of Caesalpinia decapetala in alloxan-induced diabetic rabbits

The anti-hyperglycemic, anti-hyperlipidemic, kidney and hepatoprotective potential of Caesalpinia decapetala were evaluated in alloxan-induced diabetic rabbits. The plant extract showed concentration dependant significant (p<0.001) therapeutic potential in diabetic rabbits revealing improvement in lipid profile and liver and kidney functions. 300 mg/kg and 500 mg/kg oral extract were able to reduce average blood glucose levels from 250.6 mg/dL to 204.2 mg/dL and 188.2 mg/dL respectively during 14 days period, in comparison to 183.8 mg/dL of glibenclamide. There was no significant synergistic effect found, upon co-administration of both drug and extract representing the competitive binding to sulphonyl urea (SUR1), revealing possible mechanism of action for compounds in extract. Extract was found to be nephroprotective, hepatoprotective and improved lipid profile of alloxan-treated rabbits

A novel analytical Aboodh residual power series method for solving linear and nonlinear time-fractional partial differential equations with variable coefficients

The goal of this research is to develop a novel analytic technique for obtaining the approximate and exact solutions of the Caputo time-fractional partial differential equations (PDEs) with variable coefficients. We call this technique as the Aboodh residual power series method (ARPSM), because it apply the Aboodh transform along with the residual power series method (RPSM). It is based on a new version of Taylor's series that generates a convergent series as a solution. Establishing the coefficients for a series, like the RPSM, necessitates the computation of the fractional derivatives each time. As ARPSM just requires the idea of an infinite limit, we simply need a few computations to get the coefficients. This technique solves nonlinear problems without the He's polynomials and Adomian polynomials, so the small size of computation of this technique is the strength of the scheme, which is an advantage over the homotopy perturbation method and the Adomian decomposition method. The absolute and relative errors of five linear and non-linear problems are numerically examined to determine the efficacy and accuracy of ARPSM for time-fractional PDEs with variable coefficients. In addition, numerical results are also compared with other methods such as the RPSM and the natural transform decomposition method (NTDM). Some graphs are also plotted for various values of fractional orders. The results show that our technique is easy to use, accurate, and effective. Mathematica software is used to calculate the numerical and symbolic quantities in the paper

Surgical Outcome of Corrosive Induced Antropyloric strictures

Introduction: Corrosive induced upper gastrointestinal tract injuries in pediatric patients, is not easy to treat. Interestingly only few reports are available in English literature highlighting the management and surgical outcome of corrosive induced antropyloric strictures. The aim of this study was to determine the presenting features, management and outcome of patients treated at our institute with corrosive induced antropyloric strictures.Methods: This retrospective descriptive study was conducted at Paediatric Surgery Department of Children Hospital &amp; Institute of Child Health, Lahore. Medical records of patients admitted for corrosive-induced gastric out let obstruction from January 2013 to December 2018 were included. The demographic, preoperative assessment, investigations, surgical procedure and follow up details were noted in a proforma. Results were analyzed by descriptive statistics using SPSS version 20. The quantitative variables were presented as mean ± SD. Qualitative variables were presented as frequency and percentages.Results: A total of 62 patients were included in this study. The mean age at presentation was 4.9 ±3.9 years. Of these 67.7% were male and the mean weight of children at the time of surgery was 12.6 ± 5.0 kilo grams. Bathroom cleaner was ingested by 77.4%. Vomiting was seen 100% cases while abdominal pain and weight loss was seen in 38.7 %, and 80.6% respectively. We preformed Heinke-mikulicz pyloroplasty in 59(95.2%) patients, Billroth II in 1(1.6%) and gastrojejunostomy in 2(3.2) cases. Postoperatively 40 children remained well during early post- op period while leak and respiratory issue were seen in 11.9% and 13.6% patients respectively. The mean hospital stay was 27.9±11.5 days. Two patients died after surgery and the rest were discharged. Mean fallow up 15.2±70 months. Of 60 discharged children 37 (62.7%) had no issue while 4 (6.8%) had leakage from previous jejunostomy site leak other 19 patients were lost to follow up.Conclusion:We conclude that surgical treatment for Antropyloric strictures due to corrosive injuries is an acceptable option with minimal complications. However, we emphasize on the preventive measure, child-proof containers and legislations to be taken by authorities and social welfare societie

Multi-objective optimization for sustainable turning Ti6Al4V alloy using grey relational analysis (GRA) based on analytic hierarchy process (AHP).

Sustainable machining necessitates energy-efficient processes, longer tool lifespan, and greater surface integrity of the products in modern manufacturing. However, when considering Ti6Al4V alloy, these objectives turn out to be difficult to achieve as titanium alloys pose serious machinability challenges, especially at elevated temperatures. In this research, we investigate the optimal machining parameters required for turning of Ti6Al4V alloy. Turning experiments were performed to optimize four response parameters, i.e., specific cutting energy (SCE), wear rate (R), surface roughness (Ra), and material removal rate (MRR) with uncoated H13 carbide inserts in the dry cutting environment. Grey relational analysis (GRA) combined with the analytic hierarchy process (AHP) was performed to develop a multi-objective function. Response surface optimization was used to optimize the developed multi-objective function and determine the optimal cutting condition. As per the ANOVA, the interaction of feed rate and cutting speed (f × V) was found to be the most significant factor influencing the grey relational grade (GRG) of the multi-objective function. The optimized machining conditions increased the MRR and tool life by 34% and 7%, whereas, reducing the specific cutting energy and surface roughness by 6% and 2% respectively. Using Taguchi-based GRA by analytic hierarchy process (AHP) weights method, the benefits of high-speed machining Ti6Al4V through multi-response optimization were achieved

Parametric analysis of wax printing technique for fabricating microfluidic paper-based analytic devices (µPAD) for milk adulteration analysis

Accurate prediction of hydrophobic–hydrophilic channel barriers is essential in the fabrication of paper-based microfluidic devices. This research presents a detailed parametric analysis of wax printing technique for fabricating µPADs. Utilizing commonly used Grade 1 filter paper, experimental results show that the wax spreading in the paper porous structure depends on the initially deposited wax line thickness, a threshold melting temperature and melting time. Initial width of the printed line has a linear relationship with the final width of the barrier; however, a less pronounced effect of temperature was observed. Based on the spreading behavior of the molten wax at different parameters, a generalized regression model has been developed and validated experimentally. The developed model accurately predicts wax spreading in Whatman filter paper: a non-uniform distribution of pores and fibers. Finally, tests were carried out for calorimetric detection of commonly used adulterants present in milk samples

Tool wear progression and its effect on energy consumption in turning of titanium alloy (Ti-6Al-4V).

To achieve greater productivity, titanium alloy requires cutting at higher speeds (above 100 m min−1) that affects the tool life and energy consumption during the machining process. This research work correlates the wear progression and Specific Cutting Energy (SCE) in turning Ti-6Al-4V alloy using H13 tools (uncoated carbide) in dry conditions from low to high cutting speeds. Cutting condition employed in this study were selected from published wear map developed for titanium (Ti-6Al-4V alloy) with the same tool. Flank wear growth of the tool has been investigated at different length of cuts in correlation with the SCE under different cutting conditions. The useful tool life was found to be shorter at high-speed machining conditions, thus the end of useful tool life criteria (ISO 3685) was reached at a much shorter length of cuts as compared to low-speed machining conditions. The cutting conditions corresponding to high wear rate also resulted in high SCE. Finally, SCE and wear have been related by a linear relationship that can be used to monitor wear and/or SCE utilization during machining. The results help in the selection of appropriate cutting conditions that will enhance the tool life and minimize SCE consumption during machining titanium alloy

Synthesis of 5-Fluorouracil Cocrystals with Novel Organic Acids as Coformers and Anticancer Evaluation against HCT-116 Colorectal Cell Lines

5-Fluorouracil (5-FU) being a mainstream anticancer drug is under keen and detailed investigation for prodrugs formulations in order to minimize the associated side effects. Cocrystallization of 5-FU is an innovative technique for the synthesis of 5-FU prodrugs to improve its anticancer effectiveness. The present study is based on the synthesis of 5-FU supramolecular synthons with four coformers: succinic acid, cinnamic acid, malic acid, and benzoic acid utilizing acetone as a solvent. Solid state grinding followed by a slow evaporation solution method was applied. Colorless clear crystals were obtained in all the cases. The cocrystal formation was supported with the help of Fourier transform infrared (FTIR) spectroscopy and powder X-ray diffraction (PXRD). Through FTIR, the main peaks of interest in the spectrum of 5-FU were N–H (3409.02 cm–1) and carbonyl group (1647.80 cm–1), which were prominently shifted in all spectra of the cocrystals demonstrating the replacement as well as the development of already present interactions with the new ones. For 5-FU–cinnamic acid cocrystals, the anticipated peaks were observed at 1673.13 cm–1 (−C═O) and 3566.89 cm–1 (N–H) manifesting a significant change in comparison to 5-FU. Furthermore, with the help of PXRD characterization, the representative peak of 5-FU was recorded at 2θ = 28.80°. The shifting of this specific peak and development of many new ones in the spectra of cocrystals proved the development of new structural entities. Finally, the anticancer activity of all cocrystals was evaluated in comparison to that of API. All cocrystals manifest significantly greater growth inhibition potential than the main active pharmaceutical ingredient. 5-FU–Cinnamic acid (3C) was the one that proved to be the most potent anticancer agent at all four concentrations: 4.82% (12 μg/mL), 34.21% (25 μg/mL), 55.08% (50 μg/mL), and 67.29% (100 μg/mL). In short, this study proved to be a true example to enhance the anticancer potential of 5-FU following fairly easy fabrication requirements of the cocrystallization phenomenon. After the successful synthesis of these supramolecular synthons and subsequent enhancement of growth inhibition potential of 5-FU, these cocrystals can further be evaluated for in vivo trials and membrane crossing potentials in the future

Polycystic ovary syndrome: A disorder of reproductive age, its pathogenesis, and a discussion on the emerging role of herbal remedies

Polycystic ovary syndrome (PCOS) is a very common, complex, and heterogeneous endocrine disorder of women that involves a combination of environmental and genetic factors. PCOS affects women of growing age particularly at the early to late reproductive stage (15-35 years). Currently, PCOS affects 1 in every 10 women worldwide. It is characterized majorly by a raised level of androgens such as testosterone and a large number of ovarian cysts (more than 10) that cause anovulation, infertility, and irregular menstrual cycle. PCOS is also related to other endocrine and metabolic abnormalities, such as obesity, hirsutism, acne, diabetes, insulin resistance, and glucose impairment. PCOS can be treated with allopathic, ayurvedic, and natural or herbal medications along with lifestyle modifications. Herbal medicines remained in demand for numerous reasons such as high cost and side effects associated with the use of allopathic medicine and our traditional norms, which have helped humans to use more herbal products for their health benefits. Estrogenic and nonestrogenic phytochemicals present in various plant species such as Glycyrrhiza glabra L. [Fabaceae], Aloe vera (L.) Burm. f. [Asphodelaceae], Silybum marianum (L.). Gaertn. [Asteraceae], Serenoa repens (W.Bartram) Small [Arecaceae], Actaea racemosa L. [Ranunculaceae], and Angelica sinensis (Oliv.) Diels [Apiaceae] are effective and harmless. Herbal medicines are found to be cost-effective, efficacious, and a highly esteemed source of management/treatment for PCOS than allopathic medicines. In this literature review, diagnosis, signs, and symptoms of PCOS; causes of hormonal imbalance; and risk factors associated with PCOS and their management are discussed briefly, and the focus was to find out the role of herbal remedies in PCOS management